Aphthous Stomatitis Clinical Presentation: History

Imbalances in the oral mucosal microbiome have been identified in patients with recurrent aphthous stomatitis. Although no phylum-level differences were appreciated between nonulcerated sites in these patients and healthy controls, patients with recurrent aphthous stomatitis did exhibit an increased abundance of Bacteroidales species. Further investigation is required to understand if these microbiome imbalances play a causative role in aphthous stomatitis and how diet and oral hygiene influence the oral mucosal microbiome. [ 66 ]

Conditions mimicking polymyalgia rheumatica - ScienceDirect

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology , Texas Medical Association , Association of Military Dermatologists , Texas Dermatological Society

Disclosure: Nothing to disclose.

Bibliografía - Espalda

A family history of recurrent aphthous ulcers is evident in some patients. A familial connection includes a age of onset and symptoms of increased severity. Recurrent aphthous ulcer is highly correlated in identical twins. [ 88 , 89 ]

Yasui K, Kurata T, Yashiro M, Tsuge M, Ohtsuki S, Morishima T. The effect of ascorbate on minor recurrent aphthous stomatitis. Acta Paediatr. 7559 Dec 65. [Medline].

Regardless of the clinical form of recurrent aphthous ulcer, ulcers are confined to the nonkeratinized mucosa of the mouth, sparing the dorsum of the tongue, the attached gingiva, and the hard palate mucosae, which are keratinized unless the patient is HIV positive. Although patients may have submandibular lymphadenopathy, fever is rare. Most patients are otherwise well. Different gradations and their findings are as follows:

Christy L Nebesio, MD Dermatologist

Christy L Nebesio, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

Meng W, Dong Y, Liu J, Wang Z, Zhong X, Chen R, et al. A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial. Trials. 7559 May 6. 65:85. [Medline].

David P Fivenson, MD Associate Director, St Joseph Mercy Hospital Dermatology Program, Ann Arbor, Michigan

David P Fivenson, MD is a member of the following medical societies: American Academy of Dermatology , Michigan State Medical Society , Society for Investigative Dermatology , Photomedicine Society , Wound Healing Society , Michigan Dermatological Society , Medical Dermatology Society

Disclosure: Nothing to disclose.

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology , Society for Investigative Dermatology

Disclosure: Serve (d) as a director, officer, partner, employee, advisor, consultant or trustee for: Naked Biome br/ Received income in an amount equal to or greater than $755 from: Elsevier WebMD br/ StatPearls Editor.

Warren R Heymann, MD Head, Division of Dermatology, Professor, Department of Internal Medicine, Rutgers New Jersey Medical School

Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology , American Society of Dermatopathology , Society for Investigative Dermatology

Disclosure: Nothing to disclose.